Uridine Metabolism in the Goldfish Retina During Optic Nerve Regeneration: Whole Retina Studies
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چکیده
منابع مشابه
Uridine metabolism in the goldfish retina during optic nerve regeneration: whole retina studies.
Accumulation of radioactivity from [3H]uridine in incubations of whole goldfish retinas is increased in the ipsilateral retina during a period of regeneration that follows unilateral optic nerve crush. Brief incubations to investigate the nature of enhanced labeling of the acid-soluble fraction showed a peak uptake 4 days following crush, with a gradual decrease to control levels by 21 days fol...
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In goldfish, regeneration of the optic nerve following axotomy is accompanied by changes in retinal RNA metabolism. Approximately 4 days after unilateral optic nerve crush, there is an increased uptake of 'H-labeled precursors of RNA into cells of the retina as well as an increase in labeling of total retinal RNA following incubation for 3 4 h in uitro. Subfractionation indicates that the resul...
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The activities of uridine kinase (EC 2.7.1.48), uridine monophosphate (UMP) kinase (EC 2.7.1.3.14), and uridine diphosphate (UDP) kinase (EC 2.7.4.6) were measured in retinal high-speed supernatant fractions following unilateral optic nerve crush in the goldfish. The enzyme activities followed a similar time course, with initial increases 2-3 days following nerve crush, peak activity at 4 days,...
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The Pax2 transcription factor plays a crucial role in axon-guidance and astrocyte differentiation in the optic nerve head (ONH) during vertebrate visual system development. However, little is known about its function during regeneration. The fish visual system is in continuous growth and can regenerate. Müller cells and astrocytes of the retina and ONH play an important role in these processes....
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 1981
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.1981.tb01713.x